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In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Current advances in circulating inflammatory biomarkers in atherosclerosis and related cardio-cerebrovascular

Jun-Xuan Lv1, Qi Kong1, Xin Ma1

  • 1Department of Neurology, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Disorders, Clinical Center for Cardio-cerebrovascular Disease Capital Medical University, Beijing 100053, China.

Chronic Diseases and Translational Medicine
|January 23, 2018
PubMed

Insights

This review explores circulating inflammatory biomarkers for atherosclerosis (AS). Key markers like Von Willebrand factor may help assess AS development and vascular event risk.

Area of Science:

  • Cardiovascular Research
  • Inflammation Biology
  • Biomarker Discovery

Background:

  • Atherosclerosis (AS) is a chronic systemic disease impacting coronary and cerebral arteries.
  • Inflammation is central to AS initiation and progression, prompting investigation into inflammatory biomarkers.
  • Existing biomarkers may not fully capture AS complexity or predict vascular events.

Purpose of the Study:

  • To review recent research on circulating inflammatory biomarkers for atherosclerosis.
  • To identify potential surrogate markers reflecting AS development and vascular event risk.
  • To explore novel perspectives for clinical AS evaluation and risk stratification.

Main Methods:

  • Systematic review of recent scientific literature.
  • Analysis of studies focusing on major circulating inflammatory factors.
  • Identification and evaluation of specific biomarkers associated with AS.

Main Results:

  • Several inflammatory biomarkers show promise in reflecting AS processes.
  • Key markers include Von Willebrand factor, lectin-like oxidized LDL receptor-1, and soluble urokinase plasminogen activator receptor.
  • Regulated upon activation, normal T-cell expressed and secreted (RANTES), and microparticles are also discussed.

Conclusions:

  • Circulating inflammatory biomarkers offer new avenues for understanding AS.
  • These markers may improve clinical evaluation and risk stratification for AS patients.
  • Further research is needed to validate these biomarkers in clinical practice.

Keywords:
AtherosclerosisInflammatory biomarkersPlaquesRisk factors

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