[2107 hotspots review and future prospects in colorectal cancer]

Radical surgeries and(neo) adjuvant therapies have significantly prolonged survival of patients with colorectal cancer. Microinvasive surgery and function preservation become more important with the prerequisite of R0 resection. As for colorectal cancer, long term survival after laparoscopic curative surgery is proved non-inferior to its open counterpart. The new transanal approach of total mesorectal excision, while avoiding abdominal incision for extraction, may as well improve surgical quality. Local excision and the "watch and wait" strategy, though attractive for organ-preservation, are undermined by suboptimal clinical and radiographic assessment of lymph node and treatment response, respectively. Meanwhile, fresh changes are challenging long-established perioperative regiments. Shortening of adjuvant chemotherapy to 3 months reduces adverse events without compromising survival. Moving part of, or all, adjuvant courses to before surgery may improve response, thereby omitting protectomy or radiotherapy. To summarize, function preservation and quality of life has, together with survival, increasingly become the ultimate aim of colorectal cancer treatment, a field of constant evolvement.