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Topiramate-Induced Chest Pain: A Case Report
Jared L Ostroff1, Jessica N LeClair Barnet2, Marissa L Ostroff1
11 Department of Pharmacy Practice, Western New England University College of Pharmacy and Health Sciences, Springfield, MA, USA.
Journal of Pharmacy Practice
|January 23, 2018
Summary
Chest pain is a possible adverse effect of topiramate, an anticonvulsant. This case report highlights the need for increased awareness of this potential side effect in patients starting topiramate.
Area of Science:
- Neurology
- Pharmacology
Background:
- Topiramate is an anticonvulsant medication used for epilepsy and migraine prophylaxis.
- Commonly reported side effects include cognitive dulling and fatigue.
- Chest pain has not been previously documented as an adverse effect of topiramate.
Observation:
- A 38-year-old female with a seizure disorder experienced chest pain after her first dose of topiramate.
- Diagnostic workup including chest X-ray, ECG, echocardiogram, and laboratory tests did not reveal an alternative cause for the chest pain.
- Chest pain resolved upon discontinuation of topiramate.
Findings:
- The Naranjo probability scale indicated a possible causal relationship between topiramate and the reported chest pain (score of 3).
- This case suggests topiramate may be associated with chest pain as an adverse effect.
Implications:
- Clinicians should consider topiramate as a potential cause of chest pain in patients presenting with these symptoms.
- Increased awareness of this potential adverse effect is warranted to improve patient safety and diagnosis.
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