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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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siRNA - Small Interfering RNAs02:30

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
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Long non-coding RNAs in glioma progression.

Jiajie Xi1, Qiaoyi Sun1, Li Ma1

  • 1Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, PR China.

Cancer Letters
|January 23, 2018
PubMed
Summary

Long non-coding RNAs (lncRNAs) are crucial in regulating gene expression and are implicated in glioma progression. Understanding lncRNA roles offers new diagnostic and therapeutic strategies for this aggressive brain tumor.

Keywords:
Diagnostic biomarkerGliomaLncRNATherapeutic target

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Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genomics

Background:

  • Glioma is a highly malignant primary brain tumor with poor patient prognosis due to limited diagnostic and treatment options.
  • Understanding the molecular mechanisms driving glioma progression is critical for developing effective therapies.

Purpose of the Study:

  • To review the expression profiles of long non-coding RNAs (lncRNAs) in glioma.
  • To discuss the functions and mechanisms of specific lncRNAs in glioma progression.
  • To explore the potential of lncRNAs as diagnostic, prognostic, and therapeutic targets in glioma.

Main Methods:

  • Literature review of studies on lncRNA expression in glioma.
  • Analysis of functional roles and molecular mechanisms of representative lncRNAs.
  • Evaluation of lncRNAs as biomarkers and therapeutic targets.

Main Results:

  • lncRNAs are increasingly recognized as key regulators in glioma development and progression.
  • Specific lncRNAs exhibit altered expression patterns in glioma and influence tumor behavior through various molecular pathways.
  • Evidence suggests lncRNAs can serve as potential biomarkers for glioma diagnosis and prognosis.

Conclusions:

  • lncRNAs represent a promising area for advancing glioma diagnosis and treatment.
  • Further research into lncRNA functions and mechanisms is essential for clinical translation.
  • Targeting lncRNAs may offer novel therapeutic strategies for improving outcomes in glioma patients.