Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

80.4K
Overview
80.4K
Plant Cells and Tissues02:01

Plant Cells and Tissues

66.0K
Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
66.0K
Genetic Material01:20

Genetic Material

3.8K
Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
3.8K
Members Made of Elastoplastic Material01:19

Members Made of Elastoplastic Material

421
The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...
421
Bending of Members Made of Several Materials01:11

Bending of Members Made of Several Materials

629
In analyzing a structural member composed of two different materials with identical cross-sectional areas, it is crucial to understand how their distinct elastic properties affect the member's response under load. The analysis involves assessing stress and strain distributions using the transformed section concept, which accounts for variations in material properties.
Hooke's Law determines stress in each material, stating that stress is proportional to strain but varies due to each material's...
629
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.2K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of elastin degradation alleviates joint degeneration in aging mice, dogs, and human models.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Engineering cell ring organoids for efficient establishment of patient-derived orthotopic xenotransplantation (r-PDOX) model in sarcoma.

Biomaterials·2026
Same author

Corrigendum to "Single-cell RNA-seq reveals functionally distinct biomaterial degradation-related macrophage populations" [Biomaterials Oct:277 (2021) 121116].

Biomaterials·2026
Same author

Gradient intrafibrillar mineralized collagen scaffold promotes osteochondral regeneration by enhancing differentiation of SCRG1<sup>+</sup> progenitor cells.

Biomaterials·2026
Same author

Latent Factor Modeling Reveals Unexpected Spatial Heterogeneity in Human Alzheimer's Disease Brain Transcriptomes.

Computational and structural biotechnology journal·2026
Same author

Tough and hierarchically-structured silk hydrogel for artificial tendons.

Biomaterials·2026

Related Experiment Video

Updated: Feb 15, 2026

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
06:36

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

Published on: December 10, 2021

3.4K

Cell-material interactions in tendon tissue engineering.

Junxin Lin1, Wenyan Zhou1, Shan Han1

  • 1Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University-University of Edinburgh Institute, Zhejiang University, China; Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, Zhejiang University, China.

Acta Biomaterialia
|January 23, 2018
PubMed
Summary

Biomaterials can enhance tendon regeneration by guiding stem cell differentiation and modulating immune cells like macrophages. Optimizing material cues for both cell types offers a promising strategy for improved tissue repair outcomes.

Keywords:
Macrophages polarizationMaterial cuesStem cell behaviorsTendon tissue engineering

More Related Videos

Sandwich-like Microenvironments to Harness Cell/Material Interactions
06:50

Sandwich-like Microenvironments to Harness Cell/Material Interactions

Published on: August 4, 2015

8.1K
Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery
09:13

Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery

Published on: October 6, 2022

4.2K

Related Experiment Videos

Last Updated: Feb 15, 2026

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
06:36

A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects

Published on: December 10, 2021

3.4K
Sandwich-like Microenvironments to Harness Cell/Material Interactions
06:50

Sandwich-like Microenvironments to Harness Cell/Material Interactions

Published on: August 4, 2015

8.1K
Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery
09:13

Polytetrafluoroethylene PTFE as a Suture Material in Tendon Surgery

Published on: October 6, 2022

4.2K

Area of Science:

  • Biomaterials science
  • Tissue engineering
  • Immunology

Background:

  • Tendon regeneration strategies often focus on stem cell differentiation.
  • The role of innate immune cells, particularly macrophages, in response to biomaterials is increasingly recognized.
  • Previous approaches have sometimes overlooked the immunomodulatory effects of biomaterials, potentially limiting clinical success.

Purpose of the Study:

  • To review how material cues influence stem cell tenogenic differentiation and paracrine secretion.
  • To discuss the impact of macrophages on tendon healing and their response to biomaterials.
  • To propose strategies for developing immunoregenerative biomaterials that promote both stem cell differentiation and pro-resolving macrophage phenotypes for enhanced tendon regeneration.

Main Methods:

  • Review of existing literature on biomaterial properties and their effects on cellular responses.
  • Analysis of how material cues can be manipulated to direct stem cell behavior.
  • Examination of macrophage phenotypes and their role in tendon repair in response to biomaterials.

Main Results:

  • Material cues significantly impact stem cell tenogenic differentiation and paracrine signaling.
  • Macrophages exhibit diverse responses to material cues, influencing tissue regeneration outcomes.
  • Tailoring biomaterials to modulate both stem cells and macrophages is crucial for effective tendon repair.

Conclusions:

  • Optimizing biomaterial physicochemical and biomechanical properties is key for tendon regeneration.
  • Engaging with the innate immune response, specifically macrophage activation, is essential for successful tissue repair.
  • Developing biomaterials with combined cues for stem cell and macrophage modulation holds promise for novel therapeutic strategies in tendon regeneration.