Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Resistivity01:22

Resistivity

4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

6.1K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.1K
Equivalent Resistance01:16

Equivalent Resistance

1.0K
In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
1.0K
Resistance and Conductance01:25

Resistance and Conductance

534
A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
534
Rolling Resistance01:21

Rolling Resistance

683
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
683
Vascular Resistance01:20

Vascular Resistance

11.4K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
11.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of Total Contact Casting in the Treatment of Neuropathic Plantar Ulcers: An Observational Study.

Cureus·2026
Same author

Piezophototronic modulation in a 2D Ruddlesden-Popper perovskite: a pathway to strain-light synergistic self-powered intelligent sensing.

Materials horizons·2026
Same author

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis.

Journal of integrative plant biology·2026
Same author

Effectiveness of Proximal Interphalangeal Joint Block Orthosis and Metacarpophalangeal Joint Block Orthosis in the Management of Trigger Finger: A Prospective Observational Study.

Cureus·2026
Same author

Variants in glycine decarboxylase activate catabolic mechanisms of mitochondrial energy metabolism in the brain.

The Journal of biological chemistry·2026
Same author

Development of substituted 2-(4-(sulfonyl)piperazin-1-yl)quinazoline molecular hybrids as a new class of antimalarials.

RSC advances·2026

Related Experiment Video

Updated: Feb 15, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.2K

Drug resistance in Plasmodium.

Kasturi Haldar1,2, Souvik Bhattacharjee3, Innocent Safeukui1,2

  • 1Boler-ParseghianCenter for Rare and Neglected Diseases, University of Notre Dame, 103 Galvin Life Sciences, Notre Dame, Indiana 46556, USA.

Nature Reviews. Microbiology
|January 23, 2018
PubMed
Summary

Antimalarial drug resistance is increasing, threatening malaria control. Understanding artemisinin resistance mechanisms and markers is crucial for developing new treatments and preventing spread.

More Related Videos

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

14.7K
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.6K

Related Experiment Videos

Last Updated: Feb 15, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.2K
Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

14.7K
Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.6K

Area of Science:

  • Malariology
  • Drug Resistance
  • Molecular Parasitology

Background:

  • Effective antimalarials, particularly artemisinin-based combination therapies (ACTs), have significantly reduced malaria deaths globally.
  • ACTs are increasingly used for Plasmodium vivax, but resistance is emerging.
  • Resistance to artemisinins and partner drugs is causing ACT treatment failures in Southeast Asia.

Purpose of the Study:

  • To review current knowledge on markers and mechanisms of resistance to artemisinins and ACTs.
  • To highlight the challenges and urgent need for understanding resistance.
  • To inform strategies for parasite detection, new combination therapies, and prevention of resistant parasite spread.

Main Methods:

  • Review of existing literature on artemisinin and ACT resistance.
  • Identification of Kelch 13 propeller domain mutations as a key marker for artemisinin resistance in P. falciparum.
  • Exploration of proposed resistance mechanisms, including unfolded protein response activation and phosphatidylinositol 3-kinase dysregulation.

Main Results:

  • Kelch 13 mutations are the primary marker for artemisinin resistance in P. falciparum.
  • Two major resistance mechanisms have been proposed: unfolded protein response activation and proteostatic dysregulation of parasite phosphatidylinositol 3-kinase.
  • Emerging resistance threatens the efficacy of current malaria treatment strategies.

Conclusions:

  • Understanding artemisinin resistance mechanisms is critical for malaria control.
  • New strategies are needed to detect resistant parasites and develop effective combination therapies.
  • Preventing the global spread of resistant malaria parasites is an urgent priority.