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Laeverin protein expression in normal and preeclamptic placentas using tissue microarray analysis.

Mona Nystad1,2, Vasilis Sitras3,4, Cecilie Valborg Nordbakken5

  • 1Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences UiT - The Arctic University of Norway, Tromsø, Norway.

Acta Obstetricia Et Gynecologica Scandinavica
|January 23, 2018
PubMed
Summary
This summary is machine-generated.

Laeverin protein is found in all trophoblast cells in both normal and preeclamptic placentas. Its expression pattern in trophoblasts is varied and not always confined to the cell membrane.

Keywords:
Aminopeptidase-Qcytokeratin 7laeverinplacentapreeclampsiatissue microarray

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Area of Science:

  • Reproductive biology
  • Cell biology
  • Protein expression analysis

Background:

  • Laeverin is a placenta-specific protein normally found on the surface of human trophoblasts.
  • Previous research indicated higher laeverin gene expression in preeclamptic placentas and ectopic cytoplasmic expression.
  • This study aimed to further investigate laeverin protein localization in normal and preeclamptic placentas.

Purpose of the Study:

  • To investigate the protein expression patterns of laeverin in normal and preeclamptic human placentas.
  • To compare the localization of laeverin in trophoblast cells between uncomplicated and preeclamptic pregnancies.
  • To determine if laeverin expression is exclusively membrane-bound or also occurs in the cytoplasm.

Main Methods:

  • Utilized tissue microarray analysis of 72 placentas (33 preeclamptic, 39 normal).
  • Employed immunohistochemistry and immunofluorescence techniques with a specific anti-laeverin antibody.
  • Analyzed laeverin localization in syncytiotrophoblasts, cytotrophoblasts, and extravillous trophoblasts.

Main Results:

  • Laeverin expression was detected in all trophoblast cell types across both normal and preeclamptic placentas.
  • Immunohistochemistry revealed no significant difference in membrane or cytoplasmic expression between normal and preeclamptic placentas (p > 0.05).
  • Cytoplasmic laeverin expression was predominantly observed in early-onset preeclampsia cases (delivery before 34 weeks).
  • Immunofluorescence confirmed cytoplasmic laeverin expression in some preeclamptic placentas but not simultaneous membrane and cytoplasmic localization.

Conclusions:

  • Laeverin protein is ubiquitously expressed in all trophoblast cell types in both normal and preeclamptic placentas.
  • The expression pattern of laeverin in trophoblast cells is heterogeneous.
  • Laeverin expression is not strictly confined to the cell membrane and can be found in the cytoplasm, particularly in early-onset preeclampsia.