Static and dynamic pupillometry data of healthy individuals

This study sought to determine normative static and dynamic pupillometry data in different age groups in a healthy population, and to investigate the effects of age on pupillometric characteristics.

Pupillometry measurements were undertaken on 155 healthy participants using an automatic quantitative pupillometry system. Static pupillometry measurements were undertaken; these included scotopic pupil diameter (PD), mesopic PD, low photopic PD and high photopic PD values. Dynamic pupillometry measurements were undertaken, including resting diameter, amplitude of pupil contraction, latency of pupil contraction, duration of pupil contraction, velocity of pupil contraction, latency of pupil dilation, duration of pupil dilation and velocity of pupil dilation.

Overall, 69 (44.5 per cent) participants were male and 86 (55.5 per cent) were female, with a mean age of 29.7 ± 17.8 years. Neither static nor dynamic pupillometry measurements varied significantly between males and females. Age was inversely and moderately correlated with each of the static pupillometric characteristics (p < 0.05). Resting diameter, velocity of pupil contraction, and velocity of pupil dilation values were inversely and moderately correlated with age (p < 0.001, r = -0.63; p < 0.001, r = -0.47; and p < 0.001, r = -0.34, respectively). Latency of pupil contraction was positively and moderately correlated with age (p = 0.002, r = 0.29).

The current study presents population-specific normative data on static and dynamic pupillometry values in different age groups and the effect of age on pupillary characteristics.