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Updated: Feb 15, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Multicenter assessment of exclusive endoscopic endonasal approach for the treatment of 53 olfactory neuroblastomas
Ludovic de Gabory1, Benjamin Verillaud2, Cécile Rumeau3
1Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Pellegrin, Bordeaux, France.
Background:
Given the particularities of olfactory neuroblastoma (ONB) and the lack of studies on the subject, a multicenter collaborative study was conducted to assess treatment strategy.
Methods:
Fifty-three patients with ONB were included from the French Rare Head and Neck Cancer Expert Network (REFCOR) database: 16T1, 8T2, 19T3, and 10T4. All cases were treated endoscopically with skull base removal and repair in 26 cases (49%) and without external craniotomy.
Results:
The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 87% and 71%, respectively, with mean follow-up of 45.4 ± 26.5 months. The complication rate was 18.8% with 4 cases of meningitis. Pathological analysis showed positive margins in 26.8%, notably on the dura-mater and periorbita, without impairment of OS or DFS. Forty-eight patients received adjuvant radiotherapy on T ± N. Ten patients had a recurrence (18.9%). Six patients died of their disease. Prophylactic neck irradiation seemed to reduce the recurrence rate.
Conclusion:
Exclusively endoscopic treatment proved efficient and reliable in a large controlled series.
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