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Emerging Strategies of Cancer Therapy Based on Ferroptosis

Zheyu Shen1,2, Jibin Song2, Bryant C Yung2

  • 1CAS Key Laboratory of Magnetic Materials and Devices, Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 ZhongGuan West Road, Ningbo, Zhejiang, 315201, China.

Advanced Materials (Deerfield Beach, Fla.)
|January 23, 2018
PubMed

Insights

Ferroptosis, a form of cell death dependent on iron and reactive oxygen species, is a promising cancer therapy. This review summarizes strategies for inducing ferroptosis in cancer cells, bridging biology and material design.

Area of Science:

  • Biochemistry
  • Oncology
  • Material Sciences

Background:

  • Ferroptosis is a regulated cell death pathway reliant on iron and reactive oxygen species (ROS).
  • Since its discovery in 2012, various strategies have been developed to induce ferroptosis in cancer cells.
  • Existing reviews primarily focus on ferroptosis mechanisms, leaving a gap in material design applications.

Purpose of the Study:

  • To summarize emerging strategies for inducing ferroptosis in cancer therapy.
  • To bridge the gap between the biological significance of ferroptosis and material design.
  • To provide insights into future directions for ferroptosis-based cancer treatment.

Main Methods:

  • Review of current strategies for inducing ferroptosis in cancer therapy.
  • Analysis of design considerations, advantages, and limitations of these strategies.
  • Exploration of nanomaterials, clinical drugs, experimental compounds, and gene-based approaches.

Main Results:

  • A comprehensive overview of ferroptosis-inducing strategies for cancer therapy is presented.
  • Key design considerations, benefits, and drawbacks of various approaches are highlighted.
  • The review consolidates information on the application of ferroptosis in oncology.

Conclusions:

  • Ferroptosis presents a novel therapeutic avenue for cancer treatment.
  • Material design plays a crucial role in developing effective ferroptosis-inducing agents.
  • Further research is needed to optimize ferroptosis-based therapies and overcome current limitations.
Keywords:
Fenton reactioncancer therapyferroptosisiron-based nanomaterialslipid peroxidation

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