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VIIaAT complexes, procoagulant phospholipids, and thrombin generation during postprandial lipemia
A Silveira1, A Carlo2, M Adam2
1Cardiovascular Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
International Journal of Laboratory Hematology
|January 23, 2018
Summary
Postprandial lipemia increases circulating activated Factor VII complexed with antithrombin (VIIaAT), potentially contributing to cardiovascular risk. However, its impact on procoagulant phospholipid activity and thrombin generation appears minimal.
Area of Science:
- Cardiovascular Science
- Hemostasis and Thrombosis
- Metabolic Studies
Background:
- Factor VII activation is a postprandial event.
- Activated Factor VII (VIIa) can circulate bound to antithrombin (VIIaAT).
- Postprandial lipemia's effect on coagulation markers needs further investigation.
Purpose of the Study:
- To evaluate the impact of postprandial lipemia on circulating VIIaAT.
- To assess changes in procoagulant phospholipid (PPL) activity post-meal.
- To determine the effect on thrombin generation in patients with postmyocardial infarction.
Main Methods:
- Standardized oral fat tolerance test (OFTT) administered to postmyocardial infarction patients and controls.
- Analysis of plasma VIIaAT using ELISA.
- Measurement of PPL activity and thrombin generation via calibrated automated thrombogram.
Main Results:
- VIIaAT levels increased postprandially in all participants.
- Post-myocardial infarction patients exhibited a hypercoagulable state compared to controls.
- PPL activity and thrombin generation were only marginally affected by the OFTT in controls.
Conclusions:
- The postprandial rise in VIIaAT may contribute to cardiovascular risk associated with lipemia.
- Postprandial lipemia has a limited effect on PPL activity and thrombin generation.
- VIIaAT may serve as a surrogate marker for tissue factor activity in this context.
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