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Controlling the Release from Enzyme-Responsive Microcapsules with a Smart Natural Shell.

Raheleh Ravanfar1, Giovana Bonat Celli1, Alireza Abbaspourrad1

  • 1Department of Food Science, College of Agriculture and Life Sciences, Cornell University , Ithaca, New York 14853, United States.

ACS Applied Materials & Interfaces
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PubMed
Summary

Researchers developed novel lipase-sensitive microcapsules for controlled cargo release. These core-shell structures selectively deliver payloads, demonstrating potential in food applications like cheese coloring.

Keywords:
Cheddar cheeseenzyme-responsivelipasemicrocapsulewhite whey

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Area of Science:

  • Food Science and Technology
  • Materials Science
  • Biotechnology

Background:

  • Controlled release systems are crucial for targeted delivery of active compounds.
  • Enzyme-triggered release offers specificity in complex biological or food matrices.
  • Existing microencapsulation methods may lack specificity or rely on harsh conditions.

Purpose of the Study:

  • To design and fabricate a novel core-shell microcapsule system.
  • To achieve lipase-specific triggered release of entrapped cargo.
  • To demonstrate the application of these microcapsules in a food product.

Main Methods:

  • Core-shell microcapsules were constructed with a κ-carrageenan gel core, a beeswax-palmitic acid lipid layer, and a casein-poloxamer 338 polymer shell.
  • The system was designed for cargo release upon lipase enzyme activity.
  • Bixin, a natural colorant, was used as the model cargo and incorporated into Cheddar cheese.

Main Results:

  • The microcapsules successfully encapsulated the bixin colorant within the gel matrix.
  • The lipid layer was designed to be degraded by lipase, initiating cargo release.
  • The microcapsules demonstrated selective coloring of the Cheddar cheese matrix, indicating successful delivery and release.
  • The outer polymer layer provided structural integrity and facilitated transport.

Conclusions:

  • A novel, natural, and simple core-shell microcapsule system responsive to lipase was successfully developed.
  • This system enables controlled release of encapsulated cargo, triggered by enzymatic activity.
  • The microcapsules show promise for targeted delivery and functional applications in food systems, exemplified by cheese coloration.