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Updated: Feb 15, 2026

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
Published on: February 23, 2024
Science to Practice: Will Gadolinium Chelates Be Replaced by Iron Chelates in MR Imaging?
1Stefanie Spielman Professor Department of Radiology Wright Center for Innovation in Biomedical Imaging The Ohio State University Biomedical Research Tower BR 720, 460 W 12th Ave Columbus, OH 43210.
Abstract:
Boehm-Sturm et al ( 1 ) pose a possible paradigm shift in magnetic resonance (MR) imaging: the substitution of iron chelates for gadolinium chelates as paramagnetic contrast agents. The advent of nephrogenic systemic fibrosis challenges the wide-spread perception that gadolinium is benign, and that all gadolinium-based contrast agents (GBCAs) are identical. Long-term gadolinium retention in patients with normal renal function is now a disturbing fact. Unlike gadolinium, iron is an endogenous metal with a tightly regulated transport and storage mechanism. The question the article raises is therefore a compelling one.
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