Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

5.6K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.6K
Fixed Action Patterns01:06

Fixed Action Patterns

17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

281
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
281
Patterns of Fever01:26

Patterns of Fever

4.0K
Before understanding the types and patterns of fever, it is essential to know its phases.
4.0K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

334
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
334
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

256
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
256

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a 3D-Printed Model for Simulating Closed Reduction and Percutaneous Pinning of Unstable Distal Radius Fractures.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews·2026
Same author

Experimental demonstration of high space compression by optical spaceplates.

Nature communications·2026
Same author

Reduction and Association of the Scaphoid and Lunate Versus Internal Brace for Scapholunate Ligament Reconstruction.

Hand (New York, N.Y.)·2026
Same author

Evaluation of a Novel Educational Three-Dimensionally-Printed, Unstable, Distal Radius Fracture Model for Reduction and Splinting.

The Journal of the American Academy of Orthopaedic Surgeons·2026
Same author

Influence of Release Rate and Location of Release Devices of Pheromone Component endo-Brevicomin on Attraction of the Southern Pine Beetle.

Journal of chemical ecology·2025
Same author

Surgical outcomes in chronic perilunate dislocations: A systematic review.

Hand surgery & rehabilitation·2025

Related Experiment Video

Updated: Feb 15, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

18.9K

Fracture Patterns Differ Between Osteogenesis Imperfecta and Routine Pediatric Fractures.

Kranti V Peddada1, Brian T Sullivan, Adam Margalit

  • 1Department of Pediatric Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD.

Journal of Pediatric Orthopedics
|January 23, 2018
PubMed
Summary

Certain fracture patterns in children may indicate osteogenesis imperfecta (OI). Transverse and diaphyseal humerus fractures, along with olecranon fractures, are most indicative of OI, aiding in early diagnosis.

More Related Videos

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents
06:59

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents

Published on: August 14, 2018

14.1K
Establishing a Diaphyseal Femur Fracture Model in Mice
05:46

Establishing a Diaphyseal Femur Fracture Model in Mice

Published on: December 9, 2022

3.1K

Related Experiment Videos

Last Updated: Feb 15, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

18.9K
Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents
06:59

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents

Published on: August 14, 2018

14.1K
Establishing a Diaphyseal Femur Fracture Model in Mice
05:46

Establishing a Diaphyseal Femur Fracture Model in Mice

Published on: December 9, 2022

3.1K

Area of Science:

  • Pediatric Orthopedics
  • Medical Genetics
  • Skeletal Dysplasias

Background:

  • Osteogenesis imperfecta (OI) is a genetic disorder affecting bone fragility.
  • Accurate diagnosis of OI, particularly mild Type 1, is crucial for appropriate management.
  • Estimating the likelihood of OI in pediatric fractures is clinically significant.

Purpose of the Study:

  • To determine the association between specific fracture patterns and the likelihood of osteogenesis imperfecta (OI) in pediatric patients.
  • To identify radiographic indicators that can help differentiate OI fractures from typical pediatric fractures.

Main Methods:

  • Retrospective review of 29,101 pediatric fracture cases (2003-2015).
  • Inclusion criteria excluded fractures from major trauma, and OI cases identified via ICD-9 codes.
  • Comparison of fracture characteristics between 52 OI patients and 500 randomly sampled non-OI controls.

Main Results:

  • OI patients were younger at fracture (mean 5.5 years) than non-OI patients (mean 9.0 years).
  • OI patients showed higher rates of oblique, transverse, diaphyseal, and bilateral long-bone fractures.
  • Non-OI patients had more buckle, metaphyseal, and physeal fractures. Transverse humerus, olecranon, and diaphyseal humerus fractures had high likelihood ratios for OI.

Conclusions:

  • Specific fracture patterns, including transverse and diaphyseal humerus and olecranon fractures, are strongly associated with OI.
  • Conversely, physeal and supracondylar humerus fractures are less indicative of OI.
  • Radiographic fracture analysis is a valuable tool for assessing the probability of OI in pediatric cases.