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Updated: Feb 15, 2026

Murine Flexor Tendon Injury and Repair Surgery
Published on: September 19, 2016
The matricellular protein CCN1 in tissue injury repair
Ki-Hyun Kim1, Jong Hoon Won1, Naiyuan Cheng1
1Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S. Ashland Avenue, Chicago, IL, 60607, USA.
Abstract:
The expression of Ccn1 (Cyr61) is essential for cardiovascular development during embryogenesis, whereas in adulthood it is associated with inflammation, wound healing, injury repair, and related pathologies including fibrosis and cancer. Recent studies have found that CCN1 plays a critical role in promoting wound healing and tissue repair. Mechanistically, CCN1 functions through direct interaction with specific integrin receptors expressed in various cell types in the wound tissue microenvironment to coordinate diverse cellular functions for repair. Here we briefly summarize the current knowledge on the functions of CCN1 in tissue injury repair and discuss pertinent unanswered questions.
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