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Open-label study of cognitive behavioural therapy for individuals with at-risk mental state: Feasibility in the
Kazunori Matsumoto1,2,3, Noriyuki Ohmuro2, Naohisa Tsujino4
1Department of Psychiatry, Tohoku University, Graduate School of Medicine, Sendai, Japan.
Aim:
To date, most cognitive behavioural therapy (CBT) trials for individuals with at-risk metal state (ARMS) have been conducted in few Western countries and its feasibility in other regions, including Japan, has not been established.
Methods:
We designed an open-label pilot study. Fourteen ARMS participants received CBT over 6 months and were followed-up for 6 months.
Results:
Thirteen individuals completed the CBT intervention and assessments. The mean total score on the Positive and Negative Syndrome Scale improved from 60.2 to 46.0 after the intervention (Cohen's d = 1.1). The effects were maintained at the follow-up assessment. One participant transitioned to psychosis after the CBT intervention, and was the only patient who received antipsychotics.
Conclusions:
We confirmed the feasibility of the provision of CBT for ARMS in Japan. Since overprescription of antipsychotics is a matter of great concern in Japan, CBT could be a valuable alternative treatment strategy.
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