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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

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Framingham Stroke Risk Profile is related to cerebral small vessel disease progression and lower cognitive

Renske Uiterwijk1,2, Julie Staals1,3, Marjolein Huijts4

  • 1Department of Neurology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Journal of Clinical Hypertension (Greenwich, Conn.)
|January 23, 2018
PubMed

Insights

The Framingham Stroke Risk Profile (FSRP) predicts silent cerebrovascular disease progression in hypertensive patients. While FSRP correlates with brain damage, its association with cognitive decline is more robust, especially considering age.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Neuroimaging

Background:

  • The Framingham Stroke Risk Profile (FSRP) is established for predicting clinical stroke.
  • Cerebral small vessel disease (cSVD) contributes to silent brain damage and cognitive impairment.
  • Hypertension is a major risk factor for both stroke and cSVD.

Purpose of the Study:

  • To determine if the FSRP is associated with the progression of cSVD-related brain damage.
  • To investigate the association between FSRP and cognitive performance in hypertensive patients.
  • To identify key components of the FSRP that influence these outcomes.

Main Methods:

  • Longitudinal study of 90 essential hypertension patients.
  • Baseline and 9-year follow-up brain MRI scans for cSVD markers.
  • Neuropsychological assessments to evaluate cognitive function.
  • Visual rating of cSVD progression and FSRP calculation.

Main Results:

  • FSRP showed associations with progressive white matter hyperintensities and new microbleeds, but these were not significant after adjusting for age.
  • FSRP was significantly associated with lower overall cognitive performance, even after correcting for age.
  • The age component of the FSRP appeared to be the most influential factor.

Conclusions:

  • The FSRP may serve as a predictor for cognitive decline in hypertensive individuals.
  • Age is a critical factor within the FSRP for predicting cerebrovascular disease progression and cognitive outcomes.
  • Vascular risk scores, particularly those emphasizing age, could aid in managing hypertensive patients at risk for cSVD and cognitive impairment.

Keywords:
Framingham stroke risk profilecerebral small vessel diseasecognitionhypertension

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