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Associating Symptom Phenotype and Genotype in Preeclampsia.
Sandra A Founds1, Eleni Tsigas2, Dianxu Ren3
11 Magee-Womens Research Institute, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.
Biological Research for Nursing
|January 24, 2018
Summary
This study identified novel symptom-genotype associations in preeclampsia, revealing how symptoms vary by gestational age. These findings may lead to better prediction and personalized care for preeclampsia.
Area of Science:
- Obstetrics and Gynecology
- Genetics
- Maternal-Fetal Medicine
Background:
- Preeclampsia is a complex pregnancy disorder with unclear origins.
- Understanding preeclampsia phenotypes through symptom integration is crucial.
- Identifying genetic links to preeclampsia symptoms can improve patient outcomes.
Purpose of the Study:
- To identify preeclampsia symptoms by gestational age.
- To explore associations between novel preeclampsia candidate genes and symptoms.
- To characterize preeclampsia subsets for improved health outcomes.
Main Methods:
- Recruited women with preeclampsia history from a registry.
- Collected clinical, demographic, and symptom data via surveys.
- Analyzed saliva DNA for eight single-nucleotide polymorphisms (SNPs) linked to candidate genes and symptom regions.
Main Results:
- 113 out of 114 participants reported at least one of 18 symptoms.
- Symptoms showed variation across trimesters.
- Nine symptoms were significantly associated with seven SNPs, including visual disturbances and nausea/vomiting.
Conclusions:
- Novel symptom-genotype associations in preeclampsia were identified.
- Findings support future studies integrating medical records for holistic phenotyping.
- This approach may optimize prediction, prevention, and precision nursing care for preeclampsia.
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