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Related Experiment Video

Updated: Feb 15, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
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Cerebellar involvement in migraine.

Lieke Kros1,2, Chantal A Angueyra Aristizábal1, Kamran Khodakhah1

  • 11 Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA.

Cephalalgia : an International Journal of Headache
|January 24, 2018
PubMed
Summary

The cerebellum may play a role in migraine pathophysiology, despite current research focusing on other brain systems. Further investigation into cerebellar involvement could lead to new migraine treatments.

Keywords:
Migraineataxiacerebellumtrigeminal system

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Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Migraine mechanisms remain elusive, leading to undertreatment.
  • Research often overlooks the cerebellum's potential role in migraine.
  • Evidence suggests the cerebellum is implicated in migraine pathophysiology.

Purpose of the Study:

  • To review potential cerebellar involvement in migraine.
  • To explore cerebellar connections and genetic links to migraine.
  • To stimulate further research into the cerebellum's role in migraine.

Main Methods:

  • Review of neuroimaging studies.
  • Analysis of cerebellar connectivity to migraine-related brain regions.
  • Examination of comorbidities and genetic expression.

Main Results:

  • Multiple lines of evidence suggest cerebellar involvement in migraine.
  • Imaging studies, connectivity, comorbidities, and genetic data support this link.
  • The cerebellum's role is explored from diverse perspectives.

Conclusions:

  • The cerebellum's precise role in migraine requires further investigation.
  • Cerebellar dysfunction is linked to migraine pathophysiology.
  • Targeting the cerebellum may offer novel therapeutic strategies for migraine alleviation.