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Related Experiment Videos

Measuring cochlear blood flow by laser Doppler spectroscopy.

S O Short, P C Goodwin, J N Kaplan

    Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
    |December 1, 1985
    PubMed
    Summary

    Cochlear blood flow (CBF) is primarily supplied by the internal auditory artery. CBF shows autoregulation, stabilizing despite changes in blood pressure and cardiac output, similar to the central nervous system.

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    Area of Science:

    • Otolaryngology
    • Neuroscience
    • Physiology

    Background:

    • Cochlear blood flow (CBF) is crucial for auditory function.
    • Understanding CBF regulation is vital for treating hearing disorders.

    Purpose of the Study:

    • To investigate the regulation of cochlear blood flow (CBF) in guinea pigs.
    • To identify the primary source of blood supply to the cochlea.
    • To examine the relationship between CBF and systemic hemodynamic parameters.

    Main Methods:

    • Laser Doppler flowmetry was used to measure CBF in guinea pigs.
    • Investigated the effect of internal auditory canal pressure on CBF.
    • Monitored systemic blood pressure, cardiac output, and blood viscosity.

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    Main Results:

    • The internal auditory artery was identified as the primary source of CBF.
    • Local pressure on the internal auditory canal significantly reduced CBF reversibly.
    • CBF remained stable despite bilateral carotid artery occlusion, indicating autoregulation.
    • CBF changes correlated with alterations in cardiac output and blood pressure, and inversely with blood viscosity.

    Conclusions:

    • Cochlear blood flow exhibits autoregulation, similar to the central nervous system.
    • The internal auditory artery plays a key role in supplying the cochlea.
    • CBF is sensitive to changes in blood viscosity and systemic hemodynamics.