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Nonviral Delivery Systems for Cancer Gene Therapy: Strategies and Challenges

Gayong Shim1, Dongyoon Kim1, Quoc-Viet Le1

  • 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.

Current Gene Therapy
|January 24, 2018
PubMed

Insights

Gene therapy offers unique advantages for cancer treatment by regulating gene expression. This review focuses on nonviral nanostructures for efficient delivery of genetic material to target cancer genes.

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Oncology

Background:

  • Gene therapy is a promising approach for cancer treatment, enabling precise regulation of target gene expression.
  • Modulating gene expression can reduce cancer-promoting factors or enhance anti-cancer immune responses.
  • Efficient delivery of genetic material, particularly plasmid DNA, is crucial for successful gene therapy.

Purpose of the Study:

  • To review nonviral delivery strategies for cancer gene therapy.
  • To highlight target cancer genes and delivery materials used in these strategies.
  • To discuss current challenges and future perspectives in nonviral delivery for cancer therapeutics.

Main Methods:

  • Comprehensive literature review of nonviral gene delivery systems for cancer therapy.
  • Focus on nanostructures and materials employed for gene delivery.
  • Analysis of strategies targeting specific cancer genes.

Main Results:

  • Various nanostructures and materials have been investigated as nonviral gene delivery vehicles.
  • These systems aim to overcome the challenges associated with plasmid DNA delivery.
  • The review synthesizes information on different approaches for cancer gene therapy.

Conclusions:

  • Nonviral delivery systems are essential for advancing cancer gene therapy.
  • Further research is needed to address challenges and optimize delivery strategies.
  • Nonviral delivery holds significant potential for developing novel cancer therapeutics.
Keywords:
Cancer gene therapyDNAMacromolecularNonviral deliveryNonviral gene therapyTarget cancer gene.

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