Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

584
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
584
Autoimmune Disorders01:29

Autoimmune Disorders

1.9K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mixing apples and antibodies: when the Cochrane average obscures the evidence in Alzheimer's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Long-term effects of multisession gamma transcranial alternating current stimulation in Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

Diagnosis and management of frontotemporal dementia: a narrative review.

Neurodegenerative disease management·2026
Same author

Epilepsy and EEG abnormalities in neurodegenerative dementias: toward a system epilepsy framework.

Frontiers in aging neuroscience·2026
Same author

LAMB1-related adult-onset leukoencephalopathy presenting with cognitive decline: diagnostic workup and review of the literature.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Multisession gamma tACS modulates extracellular vesicle dynamics.

Brain stimulation·2026

Related Experiment Video

Updated: Feb 15, 2026

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.3K

Autoimmunity and Frontotemporal Dementia.

Antonella Alberici1, Viviana Cristillo2, Stefano Gazzina2

  • 1Neurology Clinic, Spedali Civili Hospital, Brescia, Italy.

Current Alzheimer Research
|January 24, 2018
PubMed
Summary
This summary is machine-generated.

This review explores the immune system's role in Frontotemporal Dementia (FTD). Findings suggest potential autoimmune links and new therapeutic avenues for this neurodegenerative disease.

Keywords:
AMPAFrontotemporal dementiaautoimmunitychromosomeneuroimagingtautherapy.

More Related Videos

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

4.6K
The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

33.9K

Related Experiment Videos

Last Updated: Feb 15, 2026

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.3K
A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
05:44

A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis

Published on: December 9, 2022

4.6K
The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

33.9K

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Frontotemporal Dementia (FTD) is a neurodegenerative disorder impacting behavior and language, often linked to genetic mutations like MAPT, GRN, and C9orf72.
  • These genetic factors illuminate pathways involving Tau and TDP43 protein deposition in the brain.
  • Mechanisms initiating protein aggregation in sporadic FTD cases remain largely unknown.

Purpose of the Study:

  • To conduct a comprehensive literature review on immune homeostasis in FTD.
  • To explore potential evidence-based therapeutic strategies for FTD, a condition currently lacking effective treatments.
  • To investigate the link between autoimmunity and FTD.

Main Methods:

  • A systematic search of peer-reviewed literature was performed.
  • Focus areas included autoimmunity in the central nervous system (CNS) and FTD.
  • Included studies comprised literature reviews on immunity and CNS autoimmunity, neuroimaging in autoimmune diseases, and immunomodulatory treatments.

Main Results:

  • 114 papers were included in the review.
  • Key findings covered immunity, CNS autoimmunity, neuroimaging in autoimmune diseases, and immunomodulatory approaches.
  • Only six papers specifically addressed the autoimmune hypothesis in FTD.

Conclusions:

  • This review enhances understanding of a potential immune hypothesis in FTD.
  • It suggests that targeting autoimmune pathways may offer therapeutic benefits for neurodegeneration.
  • The findings open avenues for treatments aimed at reducing or reversing FTD progression.