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Intra-amniotic inflammation and child neurodevelopment: a systematic review protocol.
Laurence Soucy-Giguère1, Cédric Gasse1,2, Yves Giguère1,3
1Reproduction, Mother and Child Health Unit, CHU de Québec-Université Laval Research Center, Université Laval, 2705, Boul. Laurier, TR-66, Québec, QC, G1V 4G2, Canada.
Systematic Reviews
|January 24, 2018
Summary
Intra-amniotic inflammation during pregnancy may impact child neurodevelopment. This systematic review examines current evidence on this association and its modifiers to guide future research.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Outcomes
- Child Neurodevelopment
Background:
- Intra-amniotic inflammation is linked to adverse pregnancy and neonatal outcomes.
- The specific effects of intra-amniotic inflammation on child neurodevelopment are not well understood.
Purpose of the Study:
- To systematically review and assess the impact of intra-amniotic inflammation on neurodevelopmental outcomes in children.
- To identify potential modifiers of this association.
Main Methods:
- Systematic review of randomized trials and cohort studies.
- Searched MEDLINE, Embase, CINAHL, and Cochrane databases.
- Assessed risk of bias and extracted data on neurodevelopmental outcomes and inflammatory markers in amniotic fluid.
Main Results:
- This section is to be filled upon completion of the review.
- The review will synthesize existing evidence on the association.
Conclusions:
- This systematic review will clarify the relationship between intra-amniotic inflammation and child neurodevelopment.
- Findings will inform future research directions and hypotheses on pathological pathways.
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