TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia.

Area of Science:

• Neuroscience
• Medical Imaging
• Biotechnology

Background:

• Neuronal network investigation requires advanced imaging tools.
• Simultaneous multimodal imaging offers enhanced insights into brain function.
• The TRIMAGE project developed a novel trimodal imaging system.

Purpose of the Study:

• To introduce and describe the novel trimodal PET/MR/EEG system.
• To highlight its capabilities for simultaneous brain imaging.
• To present its application in investigating neurological and psychiatric conditions.

Main Methods:

• Development of a cost-effective, trimodal PET/MR/EEG system with cutting-edge technology.
• Integration of a novel non-cryogenic 1.5T magnet and advanced PET scanner components (SiPM matrices, LYSO scintillators).
• System designed for brain imaging with a 260 mm inner diameter and 160 mm Field-of-View.

Main Results:

• The system enables simultaneous acquisition of molecular metabolic (PET), functional connectivity (fMRI), and electrophysiological (EEG) data.
• Preliminary performance of PET and MR components assessed.
• Initial results for schizophrenia biomarker candidates presented.

Conclusions:

• The PET/MR/EEG system provides high spatial and temporal resolution for brain imaging.
• It facilitates research into neurovascular-metabolic coupling, healthy aging, and diseases.
• The methodology lays the foundation for individual physiological and pathological fingerprints.