[Digestive absorption of calcium phosphates in man]

Area of Science:

• Biochemistry
• Gerontology
• Nutritional Science

Context:

• Bone mineral composition closely resembles di- and tricalcium phosphates.
• Oral calcium supplements are of interest for bone health.
• The insolubility of these phosphates often leads to the perception of poor calcium absorption.

Purpose:

• To evaluate the absorbability and efficacy of di- and tricalcium phosphates as oral calcium supplements.
• To assess calcium balance in elderly patients receiving these supplements.

Summary:

• Seven elderly patients were given a constant 1500 mg daily calcium intake.
• Calcium was supplied either by diet alone or by a hypocalcemic diet supplemented with di- or tricalcium phosphate.
• Positive calcium balance was maintained with calcium phosphate supplementation, particularly tricalcium phosphate.

Impact:

• Di- and tricalcium phosphates, especially tricalcium phosphate, are inexpensive, stable, and well-accepted oral calcium supplements.
• These compounds warrant further investigation for the therapy and mass prevention of senile osteoporosis.
• The findings suggest a potential role for these phosphates in managing age-related bone loss.