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Third molar agenesis as a potential marker for craniofacial deformities
Clarissa Christina Avelar Fernandez1, Christiane Vasconcellos Cruz Alves Pereira1, Ronir Raggio Luiz2
1Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Archives of Oral Biology
|January 24, 2018
Summary
Third molar agenesis is strongly linked to cleft lip and palate conditions. This finding may aid in determining risks for these craniofacial defects in affected individuals and their families.
Area of Science:
- Dentistry
- Genetics
- Craniofacial Biology
Background:
- Tooth agenesis, specifically third molar agenesis, is a common dental anomaly.
- Craniofacial deformities encompass a range of congenital conditions affecting facial structures.
- Identifying correlations between dental anomalies and craniofacial defects can aid in risk assessment.
Purpose of the Study:
- To investigate the association between third molar agenesis and craniofacial alterations.
- To determine if specific craniofacial deformities, such as cleft lip and palate, are linked to the absence of third molars.
- To explore potential genetic or developmental connections between dental and facial anomalies.
Main Methods:
- Analysis of panoramic radiographs from 550 individuals with oral clefts and 831 orthodontic patients.
- Assessment of third molar agenesis using dental records and radiographs.
- Classification of craniofacial growth patterns (SN-GoGn angle) and skeletal malocclusion (ANB angle).
Main Results:
- A high prevalence of third molar agenesis was observed in individuals with cleft lip and/or palate (55%) and their relatives (93.5%).
- Third molar agenesis showed no significant association with skeletal malocclusion.
- No correlation was found between third molar agenesis and specific craniofacial growth patterns.
Conclusions:
- Third molar agenesis is significantly associated with the developmental disturbances leading to cleft lip and palate.
- This association suggests a potential shared etiology or developmental pathway.
- Further research into the genetic and environmental factors underlying these conditions is warranted.
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