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Gene annotation bias impedes biomedical research
Winston A Haynes1,2,3, Aurelie Tomczak1,2, Purvesh Khatri4,5
1Stanford Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, California, USA.
Scientific Reports
|January 24, 2018
Abstract:
We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypotheses.
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