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Updated: Feb 15, 2026

Author Spotlight: Assessing the Reliability of Doppler Ultrasound in Measuring Leg Blood Flow
Published on: December 15, 2023
Concurrent measurement of skeletal muscle blood flow during exercise with diffuse correlation spectroscopy and
Chandan-Ganesh Bangalore-Yogananda1, Ryan Rosenberry2, Sagar Soni1
1Department of Bioengineering, The University of Texas at Arlington, 500 UTA Blvd., Arlington, TX 76010, USA.
Abstract:
Noninvasive, direct measurement of local muscle blood flow in humans remains limited. Diffuse correlation spectroscopy (DCS) is an emerging technique to measure regional blood flow at the microvascular level. In order to better understand the strengths and limitations of this novel technique, we performed a validation study by comparing muscle blood flow changes measured with DCS and Doppler ultrasound during exercise. Nine subjects were measured (all males, 27.4 ± 2.9 years of age) for a rhythmic handgrip exercise at 20% and 50% of individual maximum voluntary contraction (MVC), followed by a post-exercise recovery. The results from DCS and Doppler ultrasound were highly correlated (R = 0.99 ± 0.02). DCS was more reliable and less susceptible to motion artifact.
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