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Spatiotemporal evolution of venous narrowing in acute MS lesions

Philipp Eisele1, Kristina Szabo1, Anne Ebert1

  • 1Department of Neurology (P.E., K.S., A.E., M.P., A.G.), Universitätsmedizin Mannheim, University of Heidelberg, Mannheim; and Institute for Neuropathology (W.B.), Universitätsmedizin Göttingen, Germany.

Neurology(R) Neuroimmunology & Neuroinflammation
|January 24, 2018
PubMed
Abstract

Insights

In multiple sclerosis (MS) lesions, intralesional veins narrow during contrast enhancement, indicating potential perivascular inflammation. This finding offers insights into plaque development using susceptibility-weighted imaging (SWI).

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system.
  • Understanding the evolution of MS lesions is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the spatiotemporal changes in venous diameter within newly developing MS lesions.
  • To utilize susceptibility-weighted imaging (SWI) in a longitudinal MRI study to observe venous narrowing.

Main Methods:

  • Retrospective analysis of serial MRI scans from 18 MS patients.
  • Inclusion of susceptibility-weighted images (SWI) to visualize intralesional veins.
  • Comparison of mean venous diameter before, during, and after contrast enhancement in acute lesions.

Main Results:

  • A total of 40 acute contrast-enhancing lesions with central veins were analyzed.
  • Intralesional veins were significantly narrower (0.80 ± 0.12 mm) during contrast enhancement compared to before (1.16 ± 0.19 mm) and after (1.07 ± 0.15 mm).
  • Statistical significance (p < 0.001) was observed for all comparisons.

Conclusions:

  • Venous narrowing observed on SWI during blood-brain barrier breakdown in MS lesions may indicate perivascular inflammation.
  • Morphological changes in veins could be linked to inflammation or altered deoxygenated hemoglobin levels.
  • Findings contribute to the understanding of MS plaque development and evolution.

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