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Serum proteomic pattern in female stress urinary incontinence
Marianne Koch1,2, Wolfgang Umek1,2, Engelbert Hanzal1
1Clinical Division of General Gynecology and Gynecological Oncology, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Electrophoresis
|January 24, 2018
Summary
This study identified distinct serum protein profiles in patients with Stress Urinary Incontinence (SUI). Key proteins involved in inflammation and coagulation were elevated in SUI patients, offering new insights into SUI pathophysiology.
Area of Science:
- Biochemistry
- Proteomics
- Urology
Background:
- The underlying mechanisms of Stress Urinary Incontinence (SUI) remain unclear.
- Previous research indicated differences in urinary proteomes of SUI patients.
Purpose of the Study:
- To determine the serum proteomic signature associated with SUI.
- To validate findings from prior urinary proteomic studies.
Main Methods:
- Serum samples from 38 individuals (19 SUI, 19 controls) were analyzed.
- Proteins were digested and separated using nano High Performance Liquid Chromatography.
- Label-free quantitative mass spectrometry (quadrupole time-of-flight) was employed for peptide and protein analysis.
Main Results:
- Out of 7012 identified proteins, 33 were uniquely detected in SUI patients (induced) and 5 in controls (depleted).
- Depleted proteins are linked to immune and DNA damage responses.
- Induced proteins are associated with inflammation, cellular stress, coagulation, and cytoskeleton functions.
- Plasma serine protease inhibitor (SERPINA5) showed increased abundance in SUI patients' serum and urine.
Conclusions:
- Serum proteomic profiling reveals significant differences in patients with Stress Urinary Incontinence.
- Altered protein expression in SUI suggests involvement of inflammatory, coagulation, and cellular stress pathways.
- SERPINA5 may serve as a potential biomarker for SUI.
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