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Bone marrow-derived mononuclear cell therapy for nonischaemic dilated cardiomyopathy-A meta-analysis

Yanting Wen1, Jingjing Ding2, Bin Zhang1

  • 1Center of Translational Medicine, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, China.

European Journal of Clinical Investigation
|January 24, 2018
PubMed

Insights

Bone marrow-derived mononuclear cells (BMMNCs) transplantation moderately improves left ventricular ejection fraction (LVEF) in non-ischaemic dilated cardiomyopathy (DCM) patients. Further research with larger populations and longer follow-up is recommended.

Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Non-ischaemic dilated cardiomyopathy (DCM) poses a significant therapeutic challenge.
  • The efficacy of bone marrow-derived mononuclear cells (BMMNCs) transplantation in DCM remains debated due to conflicting trial results.

Purpose of the Study:

  • To systematically evaluate the impact of BMMNCs transplantation on left ventricular ejection fraction (LVEF) in patients with non-ischaemic DCM.
  • To synthesize evidence from randomized controlled trials (RCTs) to clarify treatment effects.

Main Methods:

  • A meta-analysis was conducted using data from seven RCTs involving 463 patients.
  • Searches were performed across PubMed, EMBASE, and the Cochrane Controlled Trials Register for relevant studies.

Main Results:

  • BMMNCs transplantation significantly improved LVEF by 3.79% (P = .007) and reduced LVESV by -24.36 mL (P = .03).
  • No significant impact on all-cause mortality was observed (OR 0.92; P = .84).
  • Improved LVEF was more pronounced with longer follow-up periods and when using pure BMMNCs compared to G-CSF-stimulated cells.

Conclusions:

  • BMMNCs transplantation offers a moderate but statistically significant improvement in LVEF for non-ischaemic DCM.
  • The findings support the need for larger RCTs with extended follow-up to further validate BMMNCs therapy.
Abstract

Keywords:
bone marrow-derived mononuclear cellmeta-analysisnonischaemic dilated cardiomyopathynonischaemic heart failure

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