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Uveoretinal Adverse Effects Presented during Systemic Anticancer Chemotherapy: a 10-Year Single Center Experience
Ah Ran Cho1, Young Hee Yoon2, June Gone Kim2
1Seoul Shinsegae Eye Center, Uijeongbu, Korea.
Journal of Korean Medical Science
|January 24, 2018
Summary
Chemotherapy can cause uveoretinal adverse events, often mild but sometimes leading to irreversible vision loss. Regular ophthalmological monitoring is crucial during cancer treatment.
Area of Science:
- Ophthalmology
- Oncology
- Pharmacology
Background:
- Presents a 10-year experience with chemotherapy-induced uveoretinal adverse events.
- Highlights the occurrence of ocular complications during systemic cancer therapy.
Purpose of the Study:
- To analyze the incidence, clinical characteristics, and outcomes of uveoretinal adverse events associated with chemotherapy.
- To assess the impact of specific chemotherapeutic agents on ocular health.
Main Methods:
- Retrospective chart review of patients undergoing systemic chemotherapy between July 2005 and June 2015.
- Inclusion criteria: patients with suspected uveoretinal disease due to chemotherapy agents.
Main Results:
- 55 patients were enrolled; breast cancer was the most common diagnosis (36.4%).
- Noninfectious anterior uveitis was the most frequent condition (21.8%). Cisplatin was the most common agent (21.8%).
- 32.7% of patients had final visual acuity worse than 20/40, with no correlation to age, sex, specific agents, or metastasis.
Conclusions:
- Chemotherapy-induced uveoretinal complications are typically mild to moderate and respond to conservative treatment.
- A significant number of patients experienced irreversible vision loss post-chemotherapy.
- Ophthalmological monitoring is essential during chemotherapy to detect and manage adverse events.
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