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Updated: Feb 15, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Arynes in the Monoarylation of Unprotected Carbohydrate Amines
Kumar Bhaskar Pal1, Mukul Mahanti1, Ulf J Nilsson1
1Centre for Analysis and Synthesis Department of Chemistry, Lund University , Box 124, 221 00 Lund, Sweden.
Abstract:
A CsF-mediated method has been developed for the N-arylation of amino sugars that affords good to excellent yields of arylated products under mild conditions involving the in situ generation of arynes. The reaction conditions tolerate a variety of common carbohydrate protecting groups and also performs exceptionally well on unprotected amino sugar derivatives. The reactions are scalable in moderate to good yields with broad scope.
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