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Allergic Reactions02:06

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Phage therapy in allergic disorders?

Andrzej Górski1,2, Ewa Jończyk-Matysiak1, Marzanna Łusiak-Szelachowska1

  • 11 Laboratory of Bacteriophages, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wrocław, Poland.

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|January 24, 2018
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Bacterial viruses (phages) show significant immunomodulating activities, offering new therapeutic potential for allergic disorders. Initial clinical data suggest phages could be used to regulate immunity and treat allergies effectively.

Keywords:
Allergyimmunomodulationinflammationphage

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Area of Science:

  • Immunology
  • Microbiology
  • Virology

Background:

  • Allergic disorders represent a significant and increasing global health burden.
  • Novel therapeutic and preventive strategies for allergies are urgently required.
  • Bacterial viruses, or phages, are increasingly recognized for their immunomodulatory functions beyond antibacterial properties.

Purpose of the Study:

  • To explore the potential of bacterial viruses (phages) in modulating immune responses relevant to allergic disorders.
  • To present evidence and initial clinical data supporting the use of phages in allergy prevention and therapy.

Main Methods:

  • Review of recent research on phage immunobiology.
  • Analysis of phage activities with potential therapeutic applications in allergic conditions.
  • Presentation of preliminary clinical findings on phage-based interventions.

Main Results:

  • Phages possess significant immunomodulating activities.
  • These activities can be harnessed for beneficial effects in allergic disorders.
  • Initial clinical data provide support for phage therapy in managing allergies.

Conclusions:

  • Phages are emerging as crucial regulators of immune homeostasis.
  • Understanding phages as immune regulators opens new avenues for immunotherapy.
  • Phage-based strategies hold promise for novel treatments of aberrant immune responses in allergies.