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Expandable intraluminal vascular graft: a feasibility study.

J C Palmaz, R R Sibbitt, F O Tio

|February 1, 1986

Summary

This study tested an expandable intraluminal graft in dog arteries, finding a 77% patency rate at 35 weeks. The graft effectively restored arterial lumens, with complete endothelialization observed.

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Area of Science:

Vascular surgery
Biomedical engineering
Interventional cardiology

Background:

Arterial stenosis and recoil pose challenges in vascular interventions.
Expandable intraluminal grafts offer a potential solution for lumen restoration.

Purpose of the Study:

To evaluate the efficacy and safety of an expandable intraluminal graft in canine arteries.
To assess graft patency, endothelialization, and potential complications like intimal hyperplasia.

Main Methods:

An expandable wire mesh graft was mounted on a balloon angioplasty catheter.
Eighteen grafts were implanted in various arteries of eight dogs.
Grafts were placed in normal and artificially stenosed arterial segments.

Main Results:

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An overall patency rate of 77% was achieved at 35 weeks post-implantation.
Complete endothelialization of patent grafts was observed by 3 weeks.
Grafts in smaller vessels or with outflow obstruction showed significant intimal hyperplasia.

Conclusions:

The expandable intraluminal graft demonstrates promising patency and endothelialization in canine arteries.
Graft design and placement considerations are crucial to minimize intimal hyperplasia.
This technology shows potential for treating arterial stenosis.