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Updated: Feb 15, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Colchicine in Renal Diseases: Present and Future
Smaragdi Marinaki1, Chrysanthi Skalioti1, J N Boletis1
1National and Kapodistrian University of Athens, Medical School, Nephrology Department and Renal Transplantation Unit, Laiko Hospital Athens, Athens, Greece.
Abstract:
Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment. Colchicine is indicated in the prevention and treatment of gouty arthritis and familial Mediterranean fever. In this review, we summarize current and potentially future pharmacologic activities of colchicine in various renal disease entities along with pharmacokinetic and pharmacodynamic properties. Additionally, we will refer to main interactions of colchicine with medications used in renal medicine, as well as dosing recommendations in patients with reduced glomerular filtration rate.
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