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Platelet function in surgical stress.

O Naesh, J T Friis, I Hindberg

    Thrombosis and Haemostasis
    |December 17, 1985
    PubMed
    Summary
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    Surgical stress activates platelets, indicated by increased beta-thromboglobulin (beta-TG) and thromboxane B2 (TXB2) levels. Platelet function changes suggest a significant stress response during and after cholecystectomy.

    Area of Science:

    • Anesthesiology
    • Surgical Stress Response
    • Platelet Physiology

    Background:

    • Surgical procedures induce physiological stress.
    • Neurolept anesthesia is commonly used for elective surgeries like cholecystectomy.
    • Platelet activation is a potential component of the surgical stress response.

    Purpose of the Study:

    • To investigate platelet activation markers during and after elective cholecystectomy under neurolept anesthesia.
    • To correlate platelet activation with the stress response, indicated by serum cortisol levels.
    • To examine the impact of surgical stress on platelet aggregation and serotonin levels.

    Main Methods:

    • Prospective study of ten patients undergoing elective cholecystectomy.
    • Measurement of plasma beta-thromboglobulin (P-beta-TG), thromboxane B2 (P-TXB2), and serotonin (P-5-HT) pre-, per-, and postoperatively.

    Related Experiment Videos

  • Assessment of intraplatelet 5-HT, serum cortisol, and platelet aggregation response to ADP.

    • Main Results:

    • Serum cortisol increased peroperatively and decreased postoperatively, reflecting the stress response.
    • Significant increases in P-beta-TG and P-TXB2 were observed, normalizing in uncomplicated cases.
    • Plasma 5-HT peaked peroperatively and remained elevated postoperatively, correlating negatively with intraplatelet 5-HT and potentially with low PO2 and pulmonary dysfunction.

    Conclusions:

    • Platelet activation occurs during surgical stress, evidenced by elevated P-beta-TG and P-TXB2.
    • Postoperative platelet refractoriness to ADP followed by increased aggregability suggests altered platelet function.
    • Elevated P-5-HT postoperatively may be linked to respiratory complications, indicating complex physiological responses to surgery.