Related Experiment Video
Updated: Feb 15, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus
Published on: October 11, 2013
Antiviral Resistance of Splenocytes in Aged Mice
Ewa Zaczyńska1, Jolanta Artym1, Maja Kocięba1
1Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Department of Experimental Therapy, Wrocław, Poland.
Abstract:
We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.
Related Concept Videos
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Antiviral System of Bacteria and Archaea: CRISPR
Resistivity
Resistance
The Effect of Aging on Tissues
Equivalent Resistance

