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[Gut human microbiota and multiple sclerosis].

M Kh Kozhieva1, M V Melnikov2, V S Rogovsky1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|January 24, 2018
PubMed
Summary
This summary is machine-generated.

Changes in gut microbiota are linked to immune-mediated central nervous system (CNS) diseases like multiple sclerosis (MS). This review explores how gut microbes influence immune and nervous system functions, detailing potential mechanisms in MS development.

Keywords:
gut microbiotamicrobiome-gut-brain axismultiple sclerosisneurotransmitters

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Area of Science:

  • Neuroimmunology
  • Microbiome Research
  • Central Nervous System (CNS) Disorders

Background:

  • Emerging evidence links gut microbiota alterations to immune-mediated CNS diseases.
  • The complex interplay between the gut microbiome, immune system, and nervous system is increasingly recognized.

Purpose of the Study:

  • To review existing literature on the impact of gut microbiota on immune and nervous system functions.
  • To elucidate potential mechanisms connecting gut microbiota dysbiosis to CNS diseases, using multiple sclerosis (MS) as a model.

Main Methods:

  • Comprehensive literature review of studies investigating the gut microbiome.
  • Analysis of research on immune and nervous system interactions.
  • Focus on mechanistic pathways relevant to multiple sclerosis.

Main Results:

  • Gut microbiota composition significantly influences both innate and adaptive immune responses.
  • Microbial metabolites and components can modulate neuroinflammation and neurodegeneration.
  • Specific alterations in gut microbial communities are associated with MS pathogenesis.

Conclusions:

  • Gut microbiota plays a critical role in regulating immune homeostasis and CNS integrity.
  • Dysbiosis of the gut microbiome represents a potential therapeutic target for CNS diseases like MS.
  • Further research is warranted to fully understand and harness the gut-brain axis in neurological disorders.