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Updated: Feb 15, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Progressive multifocal leukoencephalopathy after T-cell replete HLA-haploidentical transplantation with
Shuntaro Ikegawa1, Nobuharu Fujii1, Koh Tadokoro2
1Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan.
Abstract:
A 52-year-old man suffered from progressive multifocal leukoencephalopathy (PML) after human leukocyte antigen (HLA)-haploidentical transplantation with post-transplantation cyclophosphamide (PTCY). Mirtazapine, mefloquine, and cytarabine failed to improve his symptoms, and he finally died 4.5 months after PML onset. This is the first case report of a patient with PML after HLA-haploidentical transplantation with PTCY. Although T-cell replete HLA-haploidentical transplantation with PTCY has enabled early immune reconstitution, PML should be considered if a patient's mental condition deteriorates.
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