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Can dynamic in vitro digestion systems mimic the physiological reality?
D Dupont1, M Alric2, S Blanquet-Diot2
1a INRA Agrocampus Ouest, STLO , Rennes , France.
Critical Reviews in Food Science and Nutrition
|January 24, 2018
Summary
Dynamic in vitro digestion models offer a promising alternative to in vivo studies for understanding food's impact on health. This review evaluates eight systems, comparing their ability to mimic complex gastrointestinal processes using in vivo data.
Area of Science:
- Food science
- Gastroenterology
- Biotechnology
Background:
- Understanding food digestion is crucial for human health.
- In vivo studies are limited by ethical and financial constraints.
- Static in vitro models lack the complexity of the gastrointestinal tract.
Purpose of the Study:
- To review the in vivo validation of dynamic digestion systems.
- To assess the ability of these systems to mimic gastrointestinal processes.
- To discuss the advantages and limitations of current dynamic digestion models.
Main Methods:
- Review of eight dynamic digestion systems.
- Comparison of system performance against in vivo data.
- Analysis of validation towards in vivo data.
Main Results:
- Dynamic models show promise in mimicking gastrointestinal digestion.
- Each system demonstrates varying degrees of accuracy in replicating in vivo conditions.
- Specific aspects of food digestion that can be mimicked differ among systems.
Conclusions:
- Dynamic digestion systems offer valuable insights into food fate.
- Further refinement is needed to fully replicate in vivo complexity.
- These models are essential tools for food-health research.
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