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Related Concept Videos

Hypothalamic-Pituitary Axis01:37

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The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
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Related Experiment Video

Updated: Feb 15, 2026

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
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[Pituitary spindle cell oncocytoma].

Soledad Sosa1, Karina Danilowicz1, Santiago González Abbati2

  • 1División Endocrinología, Hospital de Clínicas José de San Martín-UBA, Buenos Aires, Argentina.

Medicina
|January 24, 2018
PubMed
Summary

Spindle cell oncocytoma, a rare sellar neoplasm, can mimic pituitary adenomas. This case highlights successful treatment with surgery and radiosurgery, leading to complete tumor disappearance.

Keywords:
hypophysisradiosurgeryspindle cell oncocytoma

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Area of Science:

  • Neuro-oncology
  • Endocrinology
  • Neurosurgery

Background:

  • Spindle cell oncocytoma is a rare, benign, non-endocrine sellar neoplasm.
  • Its similar morphology to pituitary adenomas necessitates careful surgical planning to ensure complete resection and favorable outcomes.

Observation:

  • A 60-year-old male presented with visual abnormalities and panhypopituitarism.
  • MRI revealed a sellar mass, initially presumed to be a non-functioning pituitary macroadenoma.
  • Histological diagnosis confirmed spindle cell oncocytoma.

Findings:

  • The patient underwent transsphenoidal surgery followed by radiosurgery for a residual tumor.
  • Post-treatment imaging showed progressive reduction in tumor size.
  • Four years after treatment, complete disappearance of the residual tumor was observed.

Implications:

  • Accurate diagnosis of spindle cell oncocytoma is crucial for surgical strategy and patient prognosis.
  • Multimodal treatment, including surgery and radiosurgery, can be effective for managing this rare neoplasm.
  • Reporting new cases is essential for building evidence on optimal treatment and long-term outcomes.