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Related Experiment Videos

Active immunization against hepatitis B: immunogenicity study in homosexual men.

U Bienzle, A Rohr, R Thomssen

    Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
    |November 1, 1985
    PubMed
    Summary

    A new hepatitis B vaccine was tested in 238 homosexual men. The vaccine was safe and effective, inducing antibody production in 89.7% of participants, with younger individuals showing stronger responses.

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    Area of Science:

    • Immunology
    • Vaccinology
    • Hepatology

    Background:

    • Hepatitis B virus (HBV) infection poses a significant risk, particularly in high-risk populations.
    • Effective vaccination strategies are crucial for preventing HBV transmission and infection.
    • Evaluating vaccine efficacy and immunogenicity in specific demographic groups is essential.

    Purpose of the Study:

    • To assess the safety and immunogenicity of a novel inactivated hepatitis B vaccine.
    • To determine antibody production rates and levels in response to the vaccine.
    • To investigate factors influencing immune response, such as age and prior hepatitis B exposure markers.

    Main Methods:

    • A group of 238 homosexual men received three intramuscular doses of an inactivated hepatitis B vaccine (subtype ad).

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  • Antibody production (anti-HBs) and hepatitis B infection markers were monitored.
  • Immune responses were analyzed in relation to participant age and pre-existing hepatitis B serological markers (anti-HBs, anti-HBc).
  • Immunological studies assessed T and B cell function.

    • Main Results:

    • The vaccine was well-tolerated with no major adverse events reported.
    • Antibody production was achieved in 89.7% of the vaccinated individuals.
    • Younger vaccine recipients (<30 years) demonstrated higher antibody levels compared to older individuals.
    • A significant proportion of participants with prior anti-HBs (but negative anti-HBc) showed IgM-anti-HBs production instead of a typical booster response.
    • Lower antibody levels were observed in participants who were anti-HBs negative and anti-HBc positive compared to those with prior anti-HBs or no hepatitis B markers.

    Conclusions:

    • The evaluated inactivated hepatitis B vaccine is safe and immunogenic in homosexual men.
    • Age is a significant factor influencing the magnitude of antibody response.
    • Pre-existing hepatitis B serological status impacts the vaccine's immunogenicity, with complex responses observed in certain subgroups.
    • Further immunological investigations are needed to fully elucidate the mechanisms behind varied immune responses.