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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

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Structure of the alexithymic brain: A parametric coordinate-based meta-analysis.

Pengfei Xu¹, Esther M Opmeer², Marie-José van Tol²

¹Shenzhen Key Laboratory of Affective and Social Neuroscience, Shenzhen University, Shenzhen, China; Department of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Center for Neuroimaging, Shenzhen Institute of Neuroscience, Shenzhen, China.

Neuroscience and Biobehavioral Reviews

|January 24, 2018

Summary

People with alexithymia, characterized by difficulty identifying and expressing emotions, show smaller brain volumes in key emotional processing areas. This neuroimaging meta-analysis links reduced gray matter in the insula and amygdala to alexithymia.

Keywords:

Alexithymia Amygdala Insula Meta-analysis Structural neuroimaging

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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

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Area of Science:

Neuroscience
Psychiatry
Brain Imaging

Background:

Alexithymia involves difficulties in emotional processing.
Its neuroanatomical basis is unclear due to inconsistent research findings.
Structural brain volume differences may underlie alexithymia.

Purpose of the Study:

To investigate the neuroanatomical basis of alexithymia using a meta-analysis.
To identify specific brain regions associated with alexithymia and gray matter volume.

Main Methods:

Conducted a parametric coordinate-based meta-analysis.
Included seventeen structural neuroimaging studies.
Analyzed data from 2586 individuals with varying alexithymia levels.

Main Results:

Consistently smaller gray matter volumes were found in the left insula, left amygdala, orbital frontal cortex, and striatum in individuals with high alexithymia.
These brain regions are critical for emotion perception and experience.
The findings suggest a link between reduced gray matter in these areas and alexithymia.

Conclusions:

Provides the first quantitative integration of structural neuroimaging findings for alexithymia.
Suggests that smaller volumes in specific brain areas contribute to emotional processing deficits characteristic of alexithymia.