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Electro-olfactogram Responses Before and After Aversive Olfactory Conditioning in Humans
Annachiara Cavazzana1, Sophia C Poletti2, Cagdas Guducu3
1Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany; Gösta Ekman Laboratory, Department of Psychology, Stockholm University, Frescati Hagväg 9A 106 91 Stockholm, Sweden.
Neuroscience
|January 24, 2018
Summary
Repetitive aversive odor conditioning changed peripheral olfactory system responses in humans. This demonstrates contextually induced neuroplasticity at the olfactory epithelium level.
Area of Science:
- Neuroscience
- Sensory Science
- Olfactory Research
Background:
- The peripheral olfactory system's plasticity in humans is not fully understood.
- Investigating how conditioning affects olfactory perception is crucial for understanding sensory processing.
Purpose of the Study:
- To determine if repetitive aversive odor conditioning induces changes in the human peripheral olfactory system.
- To assess olfactory discrimination and electrophysiological responses before and after conditioning.
Main Methods:
- 51 volunteers underwent odor discrimination tests and electro-olfactogram (EOG) recordings.
- An experimental group received electrical stimuli paired with one odor enantiomer ((+)-rose oxide), while a control group did not.
- Conditioning involved three sessions over consecutive days.
Main Results:
- Significant differences were observed in peripheral electrophysiological responses between the conditioned and unconditioned odor stimuli.
- The study demonstrated contextually induced changes in the olfactory epithelium.
Conclusions:
- Repetitive aversive conditioning can alter peripheral olfactory system function in humans.
- This highlights neuroplasticity within the first neuron of the olfactory pathway.
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