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Related Concept Videos

Septins01:19

Septins

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Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
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Related Experiment Video

Updated: Feb 15, 2026

Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins
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Bottom-Up In Vitro Methods to Assay the Ultrastructural Organization, Membrane Reshaping, and Curvature Sensitivity Behavior of Septins

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Meeting report - shining light on septins.

Fabrice Caudron1, Smita Yadav2

  • 1School of Biological and Chemical Sciences, Queen Mary University of London, E1 4NS London, UK f.caudron@qmul.ac.uk smitay@uw.edu.

Journal of Cell Science
|January 24, 2018
PubMed
Summary

Septins are versatile proteins that self-assemble into diverse cellular structures. Experts convened at a workshop to explore the biological functions and assembly mechanisms of these enigmatic GTP-binding proteins.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Septins are a conserved family of GTP-binding proteins.
  • They play crucial roles in cellular organization, including cytokinesis, membrane trafficking, and stress responses.
  • The diverse structures formed by septins (filaments, rings, gauzes) suggest complex and varied functions.

Purpose of the Study:

  • To discuss recent advances in septin biology.
  • To foster collaboration and identify future research directions for septin proteins.
  • To explore the assembly mechanisms and functional significance of septin structures.

Main Methods:

  • This was a workshop, not a research study, so no specific experimental methods were employed.
  • Discussions centered on existing research and theoretical models of septin function.
  • Expert presentations and group discussions formed the core of the event.

Main Results:

  • Key areas of discussion included septin structure-function relationships.
  • Advances in visualizing septin dynamics in vivo were highlighted.
  • The role of septins in various cellular processes and disease states was explored.

Conclusions:

  • Septins are essential for diverse cellular processes.
  • Further research is needed to fully elucidate their assembly dynamics and diverse biological roles.
  • The workshop successfully brought together experts to advance the field of septin biology.