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Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters00:54

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Related Experiment Video

Updated: Feb 15, 2026

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
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Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models

Published on: September 27, 2024

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Parameters Associated With Mandibular Osteoradionecrosis.

William M Mendenhall1, Carlos Suárez2,3, Eric M Genden4

  • 1Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL.

American Journal of Clinical Oncology
|January 24, 2018
PubMed
Summary
This summary is machine-generated.

Osteoradionecrosis (ORN) risk is influenced by various factors, including radiotherapy details and dental status. Minimizing radiotherapy dose and irradiated mandibular volume can reduce ORN likelihood without compromising cancer treatment efficacy.

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Area of Science:

  • Oncology
  • Oral and Maxillofacial Surgery
  • Radiation Oncology

Background:

  • Osteoradionecrosis (ORN) is a significant complication following radiotherapy for head and neck cancers.
  • The incidence of ORN ranges from 5% to 10%, with a median latency of 1-2 years.

Purpose of the Study:

  • To review factors contributing to osteoradionecrosis (ORN) risk.
  • To discuss strategies for minimizing ORN complications.

Main Methods:

  • A comprehensive literature search was conducted using PubMed for ORN publications within the last 3 years.
  • Bibliographies of identified publications were reviewed for additional relevant references.

Main Results:

  • ORN risk is multifactorial, influenced by disease characteristics, dental health, treatment modality, and radiotherapy parameters.
  • Key factors include radiotherapy dose, irradiated mandibular volume, fractionation, and tooth extractions.

Conclusions:

  • ORN risk can be mitigated by optimizing radiotherapy dose and volume to the mandible.
  • Careful treatment planning is essential to reduce ORN incidence while preventing local-regional recurrence.