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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

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Pediatric periorificial dermatitis.

Roselyn Kellen¹, Nanette B Silverberg¹

¹Department of Dermatology, Mt Sinai West of the Icahn School of Medicine, New York, New York, USA.

|January 24, 2018

Summary

This summary is machine-generated.

Periorificial dermatitis (POD) affects infants and children, often linked to corticosteroid use. Topical metronidazole and oral antibiotics are effective treatments for this facial rash.

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Area of Science:

Pediatric Dermatology
Dermatological Disorders

Background:

Periorificial dermatitis (POD) is observed in pediatric patients from 3 months old, with a slight female predominance.
A history of atopic disorders is common in patients with POD.
POD presents as erythematous to flesh-colored papules, occasionally pustules, around the mouth, nose, and eyes.

Purpose of the Study:

To review the clinical presentation, potential triggers, diagnostic criteria, and treatment options for periorificial dermatitis in children.
To highlight the importance of differentiating POD from other acneform eruptions in pediatric patients.

Main Methods:

Clinical diagnosis is key for POD.
Laboratory tests are not diagnostic for POD.
Histology of POD can resemble rosacea, necessitating differentiation from other conditions.

Main Results:

Corticosteroid exposure, particularly topical, is a frequent, though not fully understood, trigger for POD.
While steroids may offer temporary relief, disease recurrence is common upon discontinuation.
Topical metronidazole has shown success in treating pediatric POD.

Conclusions:

POD diagnosis is primarily clinical, requiring exclusion of other acneform conditions.
For severe or widespread pediatric POD, oral antibiotics like tetracycline, doxycycline, minocycline, azithromycin, or erythromycin are indicated based on patient age.