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Related Concept Videos

Viral Mutations00:36

Viral Mutations

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Related Experiment Video

Updated: Feb 15, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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HIV-Associated Psoriasis.

N Queirós1, T Torres2

  • 1Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.

Actas Dermo-Sifiliograficas
|January 24, 2018
PubMed
Summary

Managing severe psoriasis in patients with human immunodeficiency virus (HIV) is complex. Treatment requires careful consideration of systemic therapies and close monitoring for opportunistic infections and HIV progression.

Keywords:
Biological therapiesConventional systemic therapiesFototerapiaHIVImmunosuppressionInmunodepresiónPhototherapyPsoriasisTerapias biológicasTerapias sistémicas convencionalesTopical therapyTratamiento tópicoVIH

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Immunology

Background:

  • Increasing human immunodeficiency virus (HIV) prevalence and longevity on antiretroviral therapy lead to more inflammatory disorders.
  • Psoriasis, a systemic inflammatory condition, presents unique challenges in HIV-infected individuals.
  • HIV-associated psoriasis often exhibits increased severity, atypical presentations, and reduced treatment efficacy.

Purpose of the Study:

  • To review the challenges and considerations in managing moderate to severe psoriasis in the context of HIV infection.
  • To discuss potential systemic treatment options for HIV-associated psoriasis.
  • To highlight the importance of monitoring for adverse events and disease progression.

Main Methods:

  • Literature review of studies on HIV-associated psoriasis.
  • Analysis of treatment outcomes and adverse events.
  • Discussion of management strategies and monitoring protocols.

Main Results:

  • HIV-associated psoriasis is frequently more severe and less responsive to standard treatments.
  • Systemic conventional and biologic agents are potential options but require careful patient selection.
  • Close monitoring for opportunistic infections, CD4 counts, and HIV viral load is crucial.

Conclusions:

  • Management of moderate to severe HIV-associated psoriasis is challenging and requires a multidisciplinary approach.
  • Systemic therapies should be carefully considered, balancing efficacy with the risk of adverse events.
  • Regular monitoring of immune status and viral load is essential for safe and effective management.