[Multiple Resections for Metastases from Colorectal Cancer]

Area of Science:

• Oncology
• Surgical Oncology
• Gastrointestinal Oncology

Background:

• Colorectal cancer (CRC) frequently metastasizes, necessitating effective treatment strategies.
• Multiple resections of metastases are employed for managing advanced CRC.
• Clarifying the outcomes of these aggressive surgical interventions is crucial for patient management.

Observation:

• Seven patients with metastatic CRC underwent multiple resections between 2010 and the study period.
• Metastases were resected from various organs, including the lungs and liver, with a median of 3 lesions per patient.
• The median observation period post-latest resection was 17 months.

Findings:

• A 5-year survival rate of 75% and a 2-year recurrence-free survival rate of 66.7% were observed.
• Five patients remained disease-free post-resection, with three receiving chemotherapy.
• Two patients relapsed with unresectable disease, and one patient died within 24 months.

Implications:

• Multiple resections, when achieving R0 status (complete tumor removal), are associated with a relatively good prognosis in metastatic CRC.
• While not curative for all, this surgical approach can extend survival and improve outcomes for select patients.
• Further research into patient selection and adjuvant therapies may optimize results for multiple metastases resections.